Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.40 |
| ▸ | FLT1 | P17948 | 7/20 | 0.40 |
| ▸ | FLT4 | P35916 | 7/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1683473 | 0.87 | KDR (0.67) | KDR | |
| SCHEMBL1683433 | 0.81 | KDR (0.76) | KDRFGFR1FLT1CYP3A4ERBB2 | |
| SCHEMBL1683420 | 0.78 | KDR (0.72) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL1683425 | 0.78 | KDR (0.72) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL1683447 | 0.77 | KDR (0.60) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL1683445 | 0.77 | KDR (0.60) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL1683381 | 0.76 | KDR (0.77) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL1683413 | 0.76 | KDR (1.00) | KDRFGFR1FLT1FLT4FGFR2 | |
| SCHEMBL1683407 | 0.73 | KDR (0.50) | KDRCYP3A4 | |
| SCHEMBL1683477 | 0.72 | KDR (0.61) | KDRFGFR1FLT1FLT4FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539763-B1 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | claimed |