Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.53 |
| ▸ | STK10 | O94804 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | HCK | P08631 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1683460 | 1.00 | KDR (0.82) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683465 | 1.00 | KDR (0.82) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683397 | 0.90 | KDR (1.00) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683435 | 0.90 | KDR (1.00) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683394 | 0.90 | KDR (1.00) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683392 | 0.87 | KDR (0.83) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683416 | 0.86 | KDR (0.82) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683383 | 0.85 | KDR (0.74) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683386 | 0.81 | KDR (0.72) | KDRCYP3A4KCNH2FGFR1STK10 | |
| SCHEMBL1683408 | 0.81 | KDR (0.72) | KDRCYP3A4KCNH2FGFR1STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539763-B1 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | disclosed |