Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 20/20 | 0.81 |
| ▸ | CSNK2A2 | P19784 | 19/20 | 0.81 |
| ▸ | CSNK2B | P67870 | 12/20 | 0.81 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | ULK1 | O75385 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972494 | 0.90 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3HDAC1 | |
| SCHEMBL4972036 | 0.89 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3CHEK1 | |
| SCHEMBL4973629 | 0.89 | CSNK2A2 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3CHEK1 | |
| SCHEMBL10134704 | 0.86 | CSNK2A1 (0.92) | CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL4969705 | 0.84 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3HDAC1 | |
| SCHEMBL10131477 | 0.83 | CSNK2A1 (0.83) | CSNK2A1CSNK2A2CSNK2BCSNK2A3HDAC1 | |
| SCHEMBL10131225 | 0.83 | CSNK2A1 (0.76) | CSNK2A1CSNK2A2CSNK2BCSNK2A3HDAC1 | |
| SCHEMBL4972165 | 0.81 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL10131619 | 0.81 | CSNK2A1 (0.76) | CSNK2A1CSNK2A2CSNK2BCSNK2A3HDAC1 | |
| SCHEMBL4969716 | 0.81 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9062043-B2 | Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators | SENHWA BIOSCIENCES, INC. (TW) | 2015-06-23 | — | — | US | disclosed |