Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
| ▸ | ERO1A | Q96HE7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1589741 | 0.92 | NPC1 (0.49) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL1589744 | 0.92 | NPC1 (0.49) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL19695931 | 0.87 | APP (0.49) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL12723706 | 0.86 | NPC1 (0.48) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL12723506 | 0.85 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL1589946 | 0.85 | NPC1 (0.71) | NPC1RAB9AJUNNFKB1KMT2A | |
| SCHEMBL1589944 | 0.85 | NPC1 (0.71) | NPC1RAB9AJUNNFKB1KMT2A | |
| SCHEMBL9607421 | 0.83 | PDE4B (0.43) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL1590366 | 0.81 | NPC1 (0.71) | NPC1RAB9AJUNNFKB1KMT2A | |
| SCHEMBL1590369 | 0.81 | NPC1 (0.71) | NPC1RAB9AJUNNFKB1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9062076-B2 | Fused ring analogues of anti-fibrotic agents | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2015-06-23 | — | — | US | disclosed |