Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 3/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16844873 | 0.92 | NPC1 (0.37) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15069243 | 0.92 | NPC1 (0.40) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15069159 | 0.88 | NPC1 (0.46) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL16669325 | 0.86 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15068576 | 0.86 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15069315 | 0.85 | NPC1 (0.40) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15086257 | 0.85 | NPC1 (0.38) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15069035 | 0.84 | MAPT (0.44) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL15068439 | 0.83 | NPC1 (0.46) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL21301285 | 0.83 | NPC1 (0.42) | NPC1RAB9AALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095449-A1 | METHODS FOR MODULATING THE AMOUNT RNA TRANSCRIPTS | PTC THERAPEUTICS, INC. (US) | 2015-06-25 | — | — | WO | disclosed |