Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.74 |
| ▸ | CDK4 | P11802 | 6/20 | 0.74 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.74 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684643 | 0.86 | CDK2 (0.86) | CDK2CDK4CCNE1CDK1KDM4E | |
| SCHEMBL1684781 | 0.86 | CDK2 (0.53) | CDK2CDK4CCNE1CDK1KDM4E | |
| SCHEMBL1684889 | 0.84 | CDK2 (1.00) | CDK2CDK4CCNE1CDK1KDM4E | |
| SCHEMBL1684885 | 0.84 | CDK2 (0.83) | CDK2CDK4CCNE1CDK1KDM4E | |
| SCHEMBL1684709 | 0.84 | CDK2 (0.83) | CDK2CDK4CCNE1CDK1KDM4E | |
| SCHEMBL1684769 | 0.83 | CDK2 (0.50) | CDK2CDK4CCNE1CDK1KDM4E | |
| SCHEMBL1684670 | 0.82 | CDK2 (0.76) | CDK2CDK4CCNE1CDK1KDM4E | |
| SCHEMBL1684693 | 0.82 | CDK2 (0.80) | CDK2CDK4CCNE1CDK1HDAC1 | |
| SCHEMBL1684845 | 0.82 | CDK2 (0.76) | CDK2CDK4CCNE1CDK1KDM4E | |
| SCHEMBL1684908 | 0.82 | CDK2 (0.79) | CDK2CDK4CCNE1CDK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306836-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2010002985-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | claimed |