Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.81 |
| ▸ | GAA | P10253 | 7/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.81 |
| ▸ | LMNA | P02545 | 5/20 | 0.81 |
| ▸ | HTT | P42858 | 5/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.81 |
| ▸ | HPGD | P15428 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.81 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.81 |
| ▸ | CDK2 | P24941 | 3/20 | 0.80 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.80 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.80 |
| ▸ | PIM1 | P11309 | 1/20 | 0.80 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.80 |
| ▸ | FLT4 | P35916 | 1/20 | 0.80 |
| ▸ | FLT3 | P36888 | 1/20 | 0.80 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL18040747 | 0.99 | MAPT (0.83) | MAPTALDH1A1GAAKDM4ELMNA | |
| SCHEMBL1684622 | 0.91 | MAPT (0.98) | MAPTALDH1A1GAAKDM4ELMNA | |
| Bromide SCHEMBL18040791 | 0.90 | MAPT (1.00) | MAPTALDH1A1GAAKDM4ELMNA | |
| SCHEMBL14907812 | 0.89 | MAPT (0.81) | MAPTALDH1A1GAAKDM4ELMNA | |
| SCHEMBL1684637 | 0.89 | PRKD3 (1.00) | MAPTALDH1A1GAAKDM4ELMNA | |
| SCHEMBL1684705 | 0.89 | MAPT (0.81) | MAPTALDH1A1GAAKDM4ELMNA | |
| SCHEMBL1684929 | 0.89 | MAPT (0.81) | MAPTALDH1A1GAAKDM4ELMNA | |
| SCHEMBL2355935 | 0.88 | MAPT (0.75) | MAPTALDH1A1GAAKDM4ELMNA | |
| Bromide SCHEMBL18040669 | 0.88 | MAPT (0.83) | MAPTALDH1A1GAAKDM4ELMNA | |
| Bromide SCHEMBL18040657 | 0.88 | MAPT (0.83) | MAPTALDH1A1GAAKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | claimed |
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | claimed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | claimed |
| EP-2306836-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2010002985-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | claimed |
| US-20090209573-A1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2009-08-20 | — | — | US | claimed |
| EP-1804803-A4 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2008-07-30 | — | — | EP | claimed |
| CN-101083996-A | Compounds and compositions as hedgehog pathway modulators | IRM LLC (BM) | 2007-12-05 | — | — | CN | claimed |
| EP-1804803-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM, LLC (BM) | 2007-07-11 | — | — | EP | claimed |
| WO-2006050351-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2006-05-11 | — | — | WO | claimed |
| EP-3111956-B1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3111956-A1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2017-01-04 | — | — | EP | disclosed |
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | disclosed |
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| US-20090209573-A1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2009-08-20 | — | — | US | disclosed |
| EP-1804803-A4 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2008-07-30 | — | — | EP | disclosed |
| CN-101083996-A | Compounds and compositions as hedgehog pathway modulators | IRM LLC (BM) | 2007-12-05 | — | — | CN | disclosed |
| EP-1804803-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM, LLC (BM) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006050351-A2 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | BMI1, CREBBP, BAZ2A | MAPT 4026/4885ALDH1A1 2357/4885GAA 3522/4885 |
| US-20090209573-A1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | GLI1, SHH, SMO | MAPT 4520/4885ALDH1A1 2214/4885GAA 2406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.