Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16853991 | 0.94 | MAPK14 (0.39) | MKNK2MKNK1MAPK14GPR119MAPK11 | |
| SCHEMBL16854036 | 0.91 | MAPK14 (0.41) | MKNK2MKNK1MAPK14GPR119MAPK11 | |
| SCHEMBL16854001 | 0.90 | MKNK2 (0.45) | MKNK2MKNK1MAPK14GPR119MAPK11 | |
| SCHEMBL16854034 | 0.88 | MKNK2 (0.40) | MKNK2MKNK1MAPK14GPR119MAPK11 | |
| SCHEMBL16854063 | 0.88 | MKNK2 (0.40) | MKNK2MKNK1MAPK14GPR119MAPK11 | |
| SCHEMBL16854050 | 0.86 | TYK2 (0.44) | MKNK2MAPK14GPR119MAPK11CYP3A4 | |
| SCHEMBL16854040 | 0.84 | MKNK2 (0.44) | MKNK2MKNK1MAPK14 | |
| SCHEMBL16854052 | 0.81 | MAPK14 (0.42) | MAPK14GPR119MAPK11 | |
| SCHEMBL16854046 | 0.81 | TYK2 (0.42) | MAPK14MAPK11CYP3A4 | |
| SCHEMBL16854047 | 0.80 | MKNK2 (0.41) | MKNK2MKNK1MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091156-A1 | SULFOXIMINE SUBSTITUTED PYRROLOTRIAZINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-06-25 | — | — | WO | disclosed |