SCHEMBL16857782

SCHEMBL16857782

Cc1cc(C)c2c(=O)[nH]c(-n3cc(OC(=O)O)cn3)nc2c1

nearest known ligand 0.45

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 19/20 0.45
SPR P35270 1/20 0.39
EGLN3 Q9H6Z9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3035365 0.83 EGLN1 (0.65) EGLN1
SCHEMBL16857845 0.83 EGLN1 (0.46) EGLN1SPREGLN3
SCHEMBL16857900 0.81 EGLN1 (0.52) EGLN1EGLN3
SCHEMBL16551382 0.81 EGLN1 (0.68) EGLN1
SCHEMBL16857918 0.80 EGLN1 (0.45) EGLN1
SCHEMBL16857752 0.80 EGLN1 (0.47) EGLN1
SCHEMBL16857818 0.80 EGLN1 (0.50) EGLN1
SCHEMBL16857884 0.79 EGLN1 (0.44) EGLN1SPR
SCHEMBL16857875 0.79 EGLN1 (0.47) EGLN1
SCHEMBL16857726 0.78 EGLN1 (0.56) EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2396316-B1 QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2015-07-01 EP claimed