SCHEMBL16857790

SCHEMBL16857790

CSc1cc2c(=O)[nH]c(-n3cc(OC(=O)O)cn3)nc2cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 20/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16857812 0.90 EGLN1 (0.49) EGLN1
SCHEMBL16857844 0.89 EGLN1 (0.41) EGLN1
SCHEMBL16551586 0.87 EGLN1 (0.67) EGLN1
SCHEMBL3035918 0.85 EGLN1 (0.74) EGLN1
SCHEMBL16857837 0.84 EGLN1 (0.47) EGLN1
SCHEMBL16857789 0.82 EGLN1 (0.48) EGLN1
SCHEMBL16857888 0.82 EGLN1 (0.52) EGLN1
SCHEMBL16857742 0.82 EGLN1 (0.55) EGLN1
SCHEMBL16857919 0.81 EGLN1 (0.48) EGLN1
SCHEMBL16857809 0.81 EGLN1 (0.53) EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2396316-B1 QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2015-07-01 EP claimed