Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.61 |
| ▸ | SIK1 | P57059 | 1/20 | 0.49 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 3/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15562546 | 0.89 | ALK (0.65) | ALKSIK1SIK3METPAK1 | |
| SCHEMBL17273504 | 0.86 | ALK (0.56) | ALK | |
| SCHEMBL15562854 | 0.85 | ALK (0.53) | ALKMETPAK1 | |
| SCHEMBL16870793 | 0.84 | ALK (0.69) | ALKSIK1SIK3MET | |
| SCHEMBL16870924 | 0.84 | ALK (0.69) | ALKSIK1SIK3METPAK1 | |
| SCHEMBL16859959 | 0.84 | ALK (0.71) | ALKSIK1SIK3METPAK1 | |
| Hydrochloric Acid SCHEMBL16859950 | 0.83 | ALK (0.70) | ALKSIK1SIK3METPAK1 | |
| SCHEMBL15556605 | 0.82 | ALK (0.59) | ALK | |
| SCHEMBL17273493 | 0.82 | ALK (0.59) | ALK | |
| SCHEMBL15562498 | 0.81 | PAK1 (0.49) | METPAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353107-B2 | 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives as kinase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-05-31 | — | — | US | disclosed |
| US-20150336949-A1 | 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2015-11-26 | — | — | US | disclosed |
| US-20150183781-A1 | 5-(1H-Pyrazol-4-yl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2015-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183781-A1 | 5-(1H-Pyrazol-4-yl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | MAP3K1, MAP3K5, MAP3K3 | ALK 438/4885SIK1 382/4885SIK3 400/4885 |
| US-20150336949-A1 | 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | MAP3K3, MAP3K1, MAP3K6 | ALK 408/4885SIK1 340/4885SIK3 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.