Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 14/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720228 | 0.80 | ALK (0.57) | PDPK1ALKBRD4 | |
| SCHEMBL16859938 | 0.76 | PIK3CA (0.52) | PDPK1PIK3CABRD4MAP4K4TGFBR1 | |
| SCHEMBL1456024 | 0.75 | PDPK1 (1.00) | PDPK1PIK3CA | |
| SCHEMBL21626714 | 0.75 | PDPK1 (0.49) | PDPK1PIK3CAALKMAP4K4TGFBR1 | |
| SCHEMBL15154878 | 0.75 | PDPK1 (0.55) | PDPK1PIK3CAALK | |
| SCHEMBL1456750 | 0.75 | PDPK1 (0.79) | PDPK1PIK3CAALK | |
| SCHEMBL15562555 | 0.74 | PDPK1 (0.42) | PDPK1PIK3CAALKMAP4K4TGFBR1 | |
| SCHEMBL2423369 | 0.74 | PDPK1 (0.81) | PDPK1PIK3CA | |
| SCHEMBL1456557 | 0.73 | PDPK1 (0.85) | PDPK1PIK3CA | |
| SCHEMBL1457243 | 0.72 | PDPK1 (0.80) | PDPK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150183781-A1 | 5-(1H-Pyrazol-4-yl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2015-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183781-A1 | 5-(1H-Pyrazol-4-yl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | MAP3K1, MAP3K5, MAP3K3 | PDPK1 25/4885PIK3CA 48/4885ALK 438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.