Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16860797 | 0.79 | P2RY1 (0.37) | HRH1P2RY1KDM1ADPP9DPP7 | |
| SCHEMBL16861147 | 0.78 | P2RY1 (0.33) | HRH1P2RY1KDM1ADPP9DPP7 | |
| SCHEMBL16860896 | 0.75 | KDM1A (0.37) | HRH1KDM1ADPP9DPP7NOTUM | |
| SCHEMBL16860861 | 0.74 | NOTUM (0.36) | HRH1KDM1ADPP9DPP7NOTUM | |
| SCHEMBL2801668 | 0.68 | NOTUM (0.40) | HRH1P2RY1KDM1ADPP9DPP7 | |
| SCHEMBL5592359 | 0.65 | CYP1A2 (0.40) | NOTUMMAPK1NPSR1 | |
| SCHEMBL5782188 | 0.64 | MEN1 (0.41) | MAPK1 | |
| SCHEMBL14813581 | 0.61 | KMT2A (0.36) | HRH1KDM1ADPP9DPP7 | |
| SCHEMBL5779969 | 0.61 | P2RX1 (0.44) | NPSR1 | |
| SCHEMBL17256636 | 0.61 | KDM1A (0.47) | KDM1ANOTUMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087072-A2 | SPIROINDOLINE ANTIPARASITIC DERIVATIVES | Zoetis Services LLC (US) | 2016-11-02 | — | — | EP | claimed |
| WO-2015100232-A2 | SPIROINDOLINE ANTIPARASITIC DERIVATIVES | ZOETIS SERVICES LLC (US) | 2015-07-02 | — | — | WO | claimed |
| EP-3087072-A2 | SPIROINDOLINE ANTIPARASITIC DERIVATIVES | Zoetis Services LLC (US) | 2016-11-02 | — | — | EP | disclosed |
| WO-2015100232-A2 | SPIROINDOLINE ANTIPARASITIC DERIVATIVES | ZOETIS SERVICES LLC (US) | 2015-07-02 | — | — | WO | disclosed |