Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ACR | P10323 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | RHOC | P08134 | 1/20 | 0.34 |
| ▸ | RHOA | P61586 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16794424 | 1.00 | CYP2D6 (0.65) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| SCHEMBL16794322 | 1.00 | CYP2D6 (0.65) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| Acetone SCHEMBL16794405 | 0.97 | CYP2D6 (0.62) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| Acetone SCHEMBL16794404 | 0.97 | CYP2D6 (0.62) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| SCHEMBL19135677 | 0.93 | CYP2D6 (0.57) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| SCHEMBL16794486 | 0.91 | CYP2D6 (0.62) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| SCHEMBL16794484 | 0.91 | CYP2D6 (0.62) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| SCHEMBL18162905 | 0.90 | CYP2D6 (0.52) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| SCHEMBL16811839 | 0.90 | CYP2D6 (0.54) | CYP2D6RAB9ANPC1CCNA2CDK2 | |
| SCHEMBL16860011 | 0.90 | CYP2D6 (0.54) | CYP2D6RAB9ANPC1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170354643-A1 | TRIFLUOROMETHYL PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2017-12-14 | — | — | US | disclosed |
| US-9266839-B2 | Trifluoromethyl pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2016-02-23 | — | — | US | disclosed |
| US-20150183745-A1 | TRIFLUOROMETHYL PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2015-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170354643-A1 | TRIFLUOROMETHYL PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | ATP5F1A, ATP5ME, ATP5F1D | CYP2D6 2844/4885RAB9A 385/4885NPC1 1226/4885 |
| US-20150183745-A1 | TRIFLUOROMETHYL PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | ATP5F1A, ATP5ME, ATP5F1D | CYP2D6 2844/4885RAB9A 385/4885NPC1 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.