Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 6/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622625 | 0.77 | HDAC1 (0.59) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL1284451 | 0.76 | HDAC1 (0.60) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL1687435 | 0.73 | HDAC1 (0.51) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL1687432 | 0.70 | HDAC1 (0.57) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL1283045 | 0.66 | HDAC1 (0.50) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL1621763 | 0.66 | HDAC1 (0.61) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL1285118 | 0.66 | HDAC1 (0.61) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL31659015 | 0.66 | HDAC1 (0.55) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL1284350 | 0.66 | HDAC1 (0.55) | HDAC1PIK3R1PIK3CAHDAC3MTOR | |
| SCHEMBL17078427 | 0.65 | HDAC1 (1.00) | HDAC1PIK3R1PIK3CAHDAC3MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885PIK3R1 106/4885PIK3CA 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.