Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.45 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.45 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | STK16 | O75716 | 1/20 | 0.45 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178246 | 0.82 | PIK3CA (0.51) | PIK3CAHDAC6HDAC8PIK3CBPIK3CD | |
| SCHEMBL13178194 | 0.81 | PIK3CA (0.49) | PIK3CAHDAC6HDAC8PIK3CBPIK3CD | |
| SCHEMBL12995025 | 0.81 | PIK3CA (0.54) | PIK3CAPIK3CBPIK3CDPIK3CGABCC4 | |
| SCHEMBL12994736 | 0.80 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CDPIK3CGABCC4 | |
| SCHEMBL1622034 | 0.79 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CDPIK3CGABCC4 | |
| SCHEMBL12994702 | 0.79 | PIK3CA (0.51) | PIK3CAPIK3CBPIK3CDPIK3CGABCC4 | |
| SCHEMBL12313618 | 0.79 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL13178303 | 0.78 | PIK3CA (0.49) | PIK3CAHDAC6HDAC8PIK3CBPIK3CD | |
| SCHEMBL12994731 | 0.78 | PIK3CA (0.56) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL12994793 | 0.78 | PIK3CA (0.56) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | PIK3CA 57/4885HDAC6 123/4885HDAC8 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.