Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 20/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1687265 | 1.00 | AVPR1B (0.49) | AVPR1B | |
| SCHEMBL1687272 | 0.90 | AVPR1B (0.52) | AVPR1B | |
| SCHEMBL1687275 | 0.90 | AVPR1B (0.52) | AVPR1B | |
| SCHEMBL12319869 | 0.88 | AVPR1B (0.50) | AVPR1B | |
| SCHEMBL1687413 | 0.86 | AVPR1B (0.58) | AVPR1B | |
| SCHEMBL1687417 | 0.86 | AVPR1B (0.58) | AVPR1B | |
| SCHEMBL1687136 | 0.84 | AVPR1B (0.52) | AVPR1B | |
| SCHEMBL1687223 | 0.82 | AVPR1B (0.50) | AVPR1B | |
| SCHEMBL1687423 | 0.81 | AVPR1B (0.74) | AVPR1B | |
| SCHEMBL1687302 | 0.80 | AVPR1B (0.75) | AVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066640-B1 | 2-(1-OXO-1H-ISOQUINOLIN-2-YL) ACETAMIDE DERIVATIVES | ORGANON NV (NL) | 2011-09-07 | — | — | EP | disclosed |
| US-7906504-B2 | N-tert-Butyl-2-[3-(4-fluoro-3-methoxyphenyl)-1-oxo-7-(3-pyrrolidin-1-ylpropoxy)-1H-isoquinolin-2-yl]acetamide; 2-[3-(3-Chlorophenyl)-7-((S)-2-methyl-3-pyrrolidin-1-ylpropoxy)-1-oxo-1H-isoquinolin-2-yl]-N-isopropylacetamide; antidepressants; hypothalamo-pituitary-adrenal axis modulators | N.V. ORGANON (NL) | 2011-03-15 | — | — | US | disclosed |