Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.67 |
| ▸ | KIF11 | P52732 | 11/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toluene SCHEMBL27552448 | 0.86 | POLB (0.51) | GSRKIF11POLBKMT2ATDP1 | |
| Lysine SCHEMBL28214073 | 0.86 | GSR (0.91) | GSRPOLBKMT2ATDP1DPP8 | |
| Biphenyl SCHEMBL29089102 | 0.85 | GSR (0.65) | GSRKIF11POLBKMT2ATDP1 | |
| Lysine SCHEMBL28249816 | 0.85 | GSR (0.69) | GSRKIF11POLBKMT2ATDP1 | |
| Lysine SCHEMBL28249818 | 0.85 | GSR (0.69) | GSRKIF11POLBKMT2ATDP1 | |
| Lysine SCHEMBL29288699 | 0.84 | GSR (0.62) | GSRKIF11POLBKMT2ATDP1 | |
| Lysine SCHEMBL29288698 | 0.84 | GSR (0.62) | GSRKIF11POLBKMT2ATDP1 | |
| Aminodiphenylmethane SCHEMBL23925166 | 0.83 | GSR (0.67) | GSRKIF11POLBKMT2ATDP1 | |
| Phthalic Acid SCHEMBL19210210 | 0.83 | GSR (0.67) | GSRKIF11POLBKMT2ATDP1 | |
| Anthraquinone SCHEMBL8876801 | 0.83 | GSR (0.67) | GSRKIF11POLBKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089986-A1 | CRYSTALLINE SALTS OF (Z)-O-OCTADEC-9-EN-1-YL O,O-DIHYDROGEN PHOSPHOROTHIOATE | Rxbio Inc. (US) | 2016-11-09 | — | — | EP | disclosed |
| WO-2015102856-A1 | CRYSTALLINE SALTS OF (Z)-O-OCTADEC-9-EN-1-YL O,O-DIHYDROGEN PHOSPHOROTHIOATE | RXBIO INC. (US) | 2015-07-09 | — | — | WO | disclosed |