Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LONP1 | P36776 | 14/20 | 0.63 |
| ▸ | PSMB5 | P28074 | 14/20 | 0.63 |
| ▸ | PSMB8 | P28062 | 9/20 | 0.63 |
| ▸ | PSMB9 | P28065 | 9/20 | 0.63 |
| ▸ | PSMB6 | P28072 | 9/20 | 0.63 |
| ▸ | PSMB10 | P40306 | 9/20 | 0.63 |
| ▸ | PSMB11 | A5LHX3 | 8/20 | 0.63 |
| ▸ | PSMA7 | O14818 | 8/20 | 0.63 |
| ▸ | PSMB1 | P20618 | 8/20 | 0.63 |
| ▸ | PSMA1 | P25786 | 8/20 | 0.63 |
| ▸ | PSMA2 | P25787 | 8/20 | 0.63 |
| ▸ | PSMA3 | P25788 | 8/20 | 0.63 |
| ▸ | PSMA4 | P25789 | 8/20 | 0.63 |
| ▸ | PSMA5 | P28066 | 8/20 | 0.63 |
| ▸ | PSMB4 | P28070 | 8/20 | 0.63 |
| ▸ | PSMB3 | P49720 | 8/20 | 0.63 |
| ▸ | PSMB2 | P49721 | 8/20 | 0.63 |
| ▸ | PSMA6 | P60900 | 8/20 | 0.63 |
| ▸ | PSMA8 | Q8TAA3 | 8/20 | 0.63 |
| ▸ | PSMB7 | Q99436 | 8/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688083 | 0.91 | PSMB5 (0.67) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| SCHEMBL16518652 | 0.84 | PSMB5 (0.72) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| SCHEMBL15046080 | 0.80 | PSMB5 (0.82) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| SCHEMBL7921175 | 0.80 | PSMB5 (0.82) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| SCHEMBL28694235 | 0.79 | PSMB5 (0.80) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| Bortezomib SCHEMBL8035134 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| Bortezomib SCHEMBL192129 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| Bortezomib SCHEMBL8099424 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| Bortezomib SCHEMBL466239 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB8PSMB9PSMB6 | |
| Bortezomib SCHEMBL29377226 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB8PSMB9PSMB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047845-A1 | BORTEZOMIB FORMULATIONS STABILISED WITH BORIC | APP PHARMACEUTICALS (US) | 2012-04-12 | — | — | WO | disclosed |