Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27586670 | 0.84 | NISCH (0.63) | NISCHBRD4MTORADKKDM4E | |
| SCHEMBL1288737 | 0.84 | NISCH (0.53) | NISCHBRD4MTORADKVCP | |
| SCHEMBL1838153 | 0.79 | NISCH (0.58) | NISCHBRD4MTORADKKDM4E | |
| SCHEMBL1688469 | 0.79 | NISCH (0.49) | NISCHKDRMTORADKVCP | |
| SCHEMBL27586669 | 0.79 | NISCH (0.49) | NISCHBRD4MTORADKVCP | |
| SCHEMBL7832944 | 0.79 | NISCH (0.58) | NISCHBRD4MTORADKVCP | |
| Hydrochloric Acid SCHEMBL27817951 | 0.78 | NISCH (0.56) | NISCHBRD4MTORADKKDM4E | |
| SCHEMBL9495458 | 0.77 | NISCH (0.54) | NISCHBRD4MTORADKVCP | |
| SCHEMBL3649556 | 0.76 | NISCH (0.58) | NISCHNTRK1BRD4MTORADK | |
| SCHEMBL7060159 | 0.76 | NISCH (0.49) | NISCHCSNK1A1TYRO3DYRK1BBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |