Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.79 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.76 |
| ▸ | CASP7 | P55210 | 3/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | BLM | P54132 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | VDR | P11473 | 2/20 | 0.76 |
| ▸ | USP2 | O75604 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | MDM4 | O15151 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.76 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.76 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.76 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29496910 | 0.88 | GPBAR1 (0.88) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| SCHEMBL22572513 | 0.88 | GPBAR1 (0.88) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| SCHEMBL15896184 | 0.88 | GPBAR1 (1.00) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| SCHEMBL18576111 | 0.88 | GPBAR1 (0.80) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| SCHEMBL593585 | 0.88 | GPBAR1 (1.00) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| SCHEMBL592954 | 0.88 | GPBAR1 (1.00) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| SCHEMBL592955 | 0.88 | GPBAR1 (1.00) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| SCHEMBL22192109 | 0.88 | GPBAR1 (1.00) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| SCHEMBL20065894 | 0.88 | GPBAR1 (1.00) | GPBAR1EPHA2CASP7HIF1ATP53 | |
| Epicoprosterol SCHEMBL24632942 | 0.88 | OSBP (0.78) | GPBAR1EPHA2CASP7HIF1ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047495-A2 | METHODS FOR PREPARING SYNTHETIC BILE ACIDS AND COMPOSITIONS COMPRISING THE SAME | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |