Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.55 |
| ▸ | CDK2 | P24941 | 14/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16893089 | 0.83 | AURKA (0.75) | AURKACDK2MAPK1MAP3K7FLT3 | |
| SCHEMBL16893050 | 0.79 | AURKA (0.63) | AURKACDK2MAPK1MAP3K7FLT3 | |
| SCHEMBL16892980 | 0.79 | AURKA (0.65) | AURKACDK2MAPK1MAP3K7FLT3 | |
| SCHEMBL16893023 | 0.79 | AURKA (0.54) | AURKACDK2MAPK1FLT3JAK2 | |
| SCHEMBL16893115 | 0.78 | AURKA (0.67) | AURKACDK2MAPK1MAP3K7FLT3 | |
| SCHEMBL16893001 | 0.78 | AURKA (0.54) | AURKACDK2MAPK1FLT3JAK2 | |
| SCHEMBL16893070 | 0.78 | AURKA (0.66) | AURKACDK2MAPK1MAP3K7FLT3 | |
| SCHEMBL16893053 | 0.77 | AURKA (0.66) | AURKACDK2MAPK1MAP3K7FLT3 | |
| SCHEMBL16893123 | 0.77 | AURKA (0.65) | AURKACDK2MAPK1MAP3K7FLT3 | |
| SCHEMBL16893094 | 0.77 | AURKA (0.54) | AURKACDK2MAPK1FLT3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363906-B1 | HETEROCYCLIC INHIBITORS OF ERK2 AND USES THEREOF | VERTEX PHARMA (US) | 2015-07-15 | — | — | EP | claimed |