Sugi Predict

Sugi Predict / Compounds / SCHEMBL16893389

SCHEMBL16893389

SCHEMBL16893389

CCOC(=O)Cc1cc(C(=NOC)c2ccc(OC)cc2)sc1-c1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.49
▸ KMT2A Q03164 4/20 0.49
▸ RXFP1 Q9HBX9 1/20 0.49
▸ MAPT P10636 6/20 0.44
▸ TP53 P04637 4/20 0.44
▸ PTGS2 P35354 3/20 0.42
▸ RAB9A P51151 4/20 0.40
▸ HPGD P15428 4/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ KDM4E B2RXH2 2/20 0.40
▸ HSD17B10 Q99714 2/20 0.40
▸ GLA P06280 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ PTPN11 Q06124 1/20 0.39
▸ GRM6 O15303 1/20 0.39
▸ POLB P06746 1/20 0.38
▸ NPC1 O15118 3/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19413881 0.94 KMT2A (0.49) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL16893461 0.94 KMT2A (0.49) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL16893488 0.91 MEN1 (0.50) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL16893467 0.91 MEN1 (0.50) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL15546807 0.88 MEN1 (0.63) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL16893408 0.87 MEN1 (0.58) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL16907763 0.85 MEN1 (0.52) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL18035681 0.85 MEN1 (0.61) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL19413876 0.85 MEN1 (0.61) MEN1KMT2ARXFP1MAPTTP53
SCHEMBL15545765 0.85 MEN1 (0.61) MEN1KMT2ARXFP1MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9777015-B2 Useful thiophene derivatives in the treatment of diabetes METABRAIN RESEARCH (FR) 2017-10-03 — — US claimed
CN-104718200-B Thiophene derivant for treating diabetes 蒙塔博瑞恩研究公司 2016-11-09 — — CN claimed
EP-2875010-B1 THIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES METABRAIN RES (FR) 2016-08-31 — — EP claimed
US-9777015-B2 Useful thiophene derivatives in the treatment of diabetes METABRAIN RESEARCH (FR) 2017-10-03 — — US disclosed
US-9777015-B2 Useful thiophene derivatives in the treatment of diabetes METABRAIN RESEARCH (FR) 2017-10-03 — — US disclosed
US-20150197530-A1 USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES METABRAIN RESEARCH (FR) 2015-07-16 — — US disclosed
US-20150197530-A1 USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES METABRAIN RESEARCH (FR) 2015-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150197530-A1 USEFUL THIOPHENE DERIVATIVES IN THE TREATMENT OF DIABETES SLC5A2, SLC5A1, TPMT MEN1 4184/4885KMT2A 4602/4885RXFP1 3837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.