Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 10/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18207831 | 0.94 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18207832 | 0.94 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL17373888 | 0.90 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL17373886 | 0.90 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16898771 | 0.90 | MAPT (0.33) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16899222 | 0.89 | MAPT (0.36) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16899093 | 0.89 | MAPT (0.36) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16899140 | 0.88 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16899218 | 0.88 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18207804 | 0.86 | SMN1; SMN2 (0.43) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092226-B1 | INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2019-03-13 | — | — | EP | disclosed |
| US-10160753-B2 | Indazole compounds as IRAK4 inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-12-25 | — | — | US | disclosed |
| US-20180201609-A1 | INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-07-19 | — | — | US | disclosed |
| EP-3322698-A1 | INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2018-05-23 | — | — | EP | disclosed |
| WO-2017009798-A1 | INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-01-19 | — | — | WO | disclosed |
| EP-3092226-A1 | INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2016-11-16 | — | — | EP | disclosed |
| US-20160326151-A1 | Indazole Compounds as IRAK4 Inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-11-10 | — | — | US | disclosed |
| WO-2015104662-A1 | INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180201609-A1 | INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS | IRAK4, IRAK3, IRAK2 | KMT2A 333/4885MEN1 3410/4885SMN1; SMN2 2558/4885 |
| US-10160753-B2 | Indazole compounds as IRAK4 inhibitors | IRAK4, IRAK3, IRAK1 | KMT2A 341/4885MEN1 2151/4885SMN1; SMN2 1117/4885 |
| US-20160326151-A1 | Indazole Compounds as IRAK4 Inhibitors | IRAK4, IRAK3, IRAK1 | KMT2A 341/4885MEN1 2151/4885SMN1; SMN2 1117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.