Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.72 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.68 |
| ▸ | EED | O75530 | 7/20 | 0.66 |
| ▸ | SUZ12 | Q15022 | 7/20 | 0.66 |
| ▸ | RBBP4 | Q09028 | 5/20 | 0.66 |
| ▸ | AEBP2 | Q6ZN18 | 4/20 | 0.66 |
| ▸ | RBBP7 | Q16576 | 3/20 | 0.66 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.56 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16899505 | 0.92 | EZH2 (0.86) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16899421 | 0.89 | EZH2 (0.61) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16899646 | 0.89 | EZH2 (0.63) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16899439 | 0.86 | EZH2 (0.58) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2593962 | 0.86 | EZH2 (0.80) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16899620 | 0.85 | EZH2 (0.87) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16899579 | 0.85 | EZH2 (0.84) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16899515 | 0.84 | EZH2 (0.86) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16899424 | 0.84 | EZH2 (0.63) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16899654 | 0.84 | EZH2 (1.00) | EZH2EZH1EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | claimed |
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | disclosed |