Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 13/20 | 0.67 |
| ▸ | EED | O75530 | 3/20 | 0.65 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.65 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.65 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.65 |
| ▸ | EZH1 | Q92800 | 10/20 | 0.60 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.60 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.60 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16899532 | 0.94 | EZH2 (0.71) | EZH2EEDRBBP4SUZ12AEBP2 | |
| Hydrochloric Acid SCHEMBL16899413 | 0.93 | EZH2 (0.70) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899658 | 0.93 | EZH2 (0.78) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899480 | 0.93 | EZH2 (0.71) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899439 | 0.92 | EZH2 (0.58) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899583 | 0.90 | EZH2 (0.71) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899505 | 0.87 | EZH2 (0.86) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899537 | 0.87 | EZH2 (0.68) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899539 | 0.87 | EZH2 (0.70) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16899564 | 0.86 | EZH2 (0.57) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | claimed |
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | disclosed |