Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593133 | 0.84 | BACE1 (0.63) | BACE1BACE2 | |
| SCHEMBL2592658 | 0.84 | BACE1 (0.63) | BACE1BACE2 | |
| SCHEMBL16900330 | 0.82 | BACE1 (0.48) | BACE1BACE2 | |
| Formic Acid SCHEMBL14759734 | 0.80 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL2589234 | 0.73 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL2589230 | 0.73 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL12478872 | 0.73 | BACE1 (0.56) | BACE1BACE2 | |
| SCHEMBL12478871 | 0.73 | BACE1 (0.56) | BACE1BACE2 | |
| SCHEMBL2593010 | 0.72 | BACE1 (0.64) | BACE1BACE2 | |
| SCHEMBL2592791 | 0.72 | BACE1 (0.64) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079919-B2 | Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as BACE1 and/or BACE2 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2015-07-14 | — | — | US | disclosed |