Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | SPR | P35270 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 5/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19190172 | 1.00 | ALK (0.52) | ALKMETSPRMAP3K7IRAK1 | |
| Hydrochloric Acid SCHEMBL16895496 | 0.99 | ALK (0.51) | ALKMETSPRMAP3K7IRAK1 | |
| Hydrochloric Acid SCHEMBL16895498 | 0.99 | ALK (0.51) | ALKMETSPRMAP3K7IRAK1 | |
| SCHEMBL16901731 | 0.91 | EGFR (0.45) | ALKMETSPRMAP3K7IRAK1 | |
| SCHEMBL19190201 | 0.91 | EGFR (0.45) | ALKMETSPRMAP3K7IRAK1 | |
| Hydrochloric Acid SCHEMBL19178862 | 0.90 | EGFR (0.44) | ALKMETSPRMAP3K7IRAK1 | |
| Hydrochloric Acid SCHEMBL16895932 | 0.90 | EGFR (0.44) | ALKMETSPRMAP3K7IRAK1 | |
| SCHEMBL16895988 | 0.83 | EGFR (0.63) | ALKMETEGFRCYP3A4CYP2C9 | |
| SCHEMBL16895609 | 0.83 | EGFR (0.63) | ALKMETEGFRCYP3A4CYP2C9 | |
| SCHEMBL16896127 | 0.82 | ALK (0.50) | ALKMETSPRMAP3K7IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440957-B2 | Compounds and compositions for modulating EGFR Activity | NOVARTIS AG (CH) | 2016-09-13 | — | — | US | disclosed |
| US-9440957-B2 | Compounds and compositions for modulating EGFR Activity | NOVARTIS AG (CH) | 2016-09-13 | — | — | US | disclosed |
| US-20150197505-A1 | Compounds and Compositions for Modulating EGFR Activity | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2015-07-16 | — | — | US | disclosed |
| US-20150197505-A1 | Compounds and Compositions for Modulating EGFR Activity | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2015-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197505-A1 | Compounds and Compositions for Modulating EGFR Activity | EGFR, ERBB2, ERBB3 | ALK 257/4885MET 8/4885SPR 4488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.