Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | ITK | Q08881 | 4/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | CDK14 | O94921 | 3/20 | 0.38 |
| ▸ | CCNY | Q8ND76 | 3/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16895793 | 0.91 | EGFR (0.81) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16895561 | 0.91 | EGFR (0.81) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16895565 | 0.91 | EGFR (0.81) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16895797 | 0.91 | EGFR (0.81) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16895411 | 0.91 | EGFR (0.63) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16895934 | 0.91 | EGFR (0.63) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16895414 | 0.91 | EGFR (0.63) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16895939 | 0.91 | EGFR (0.63) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16896105 | 0.90 | EGFR (0.80) | EGFRCYP2D6CYP3A4CYP2C9ITK | |
| SCHEMBL16895729 | 0.90 | EGFR (0.80) | EGFRCYP2D6CYP3A4CYP2C9ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440957-B2 | Compounds and compositions for modulating EGFR Activity | NOVARTIS AG (CH) | 2016-09-13 | — | — | US | disclosed |
| US-20150197505-A1 | Compounds and Compositions for Modulating EGFR Activity | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2015-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197505-A1 | Compounds and Compositions for Modulating EGFR Activity | EGFR, ERBB2, ERBB3 | EGFR 1/4885CYP2D6 4785/4885CYP3A4 4848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.