Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 19/20 | 0.78 |
| ▸ | PDE10A | Q9Y233 | 16/20 | 0.78 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16917450 | 0.88 | PDE2A (0.78) | PDE2APDE10A | |
| SCHEMBL16917511 | 0.87 | PDE2A (0.80) | PDE2APDE10A | |
| SCHEMBL15471778 | 0.87 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL15472003 | 0.87 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL15472005 | 0.87 | PDE2A (1.00) | PDE2APDE10A | |
| SCHEMBL16917455 | 0.86 | PDE2A (0.77) | PDE2APDE10A | |
| SCHEMBL16917454 | 0.85 | PDE2A (0.77) | PDE2APDE10A | |
| SCHEMBL16917460 | 0.85 | PDE2A (0.65) | PDE2APDE10A | |
| SCHEMBL16917515 | 0.85 | PDE2A (0.78) | PDE2APDE10A | |
| SCHEMBL16917464 | 0.84 | PDE2A (0.77) | PDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085584-B2 | Substituted pyrido[3,2-E][1,2,4]-triazolo[4,3-A]pyrazines for the treatment of central nervous system disorders | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-21 | — | — | US | disclosed |