Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | KLK3 | P07288 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122067 | 0.92 | BTK (0.51) | BTKPTGS2FYNTNK2KLK3 | |
| SCHEMBL121344 | 0.87 | BTK (0.50) | BTKTNK2FFAR1FFAR4 | |
| SCHEMBL169858 | 0.84 | BTK (0.49) | BTKTNK2FFAR1FFAR4 | |
| SCHEMBL170174 | 0.80 | BTK (0.52) | BTKPTGS2FYNTNK2FFAR1 | |
| SCHEMBL123836 | 0.78 | BTK (0.48) | BTKTNK2HTR2A | |
| SCHEMBL120777 | 0.78 | BTK (0.44) | BTKTNK2EGLN2ALOX5APDHPS | |
| SCHEMBL169241 | 0.77 | BTK (0.51) | BTKFYNTNK2FFAR1FFAR4 | |
| SCHEMBL125087 | 0.76 | BTK (0.53) | BTKFYNTNK2FFAR1TP53 | |
| SCHEMBL122380 | 0.75 | BTK (0.53) | BTKFYNTNK2FFAR1DHPS | |
| SCHEMBL169866 | 0.75 | BTK (0.50) | BTKFYNTNK2DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424368-A1 | PYRROLOTRIAZINE COMPOUNDS | Locus Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126960-A1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |