Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990033 | 0.90 | GRM5 (0.58) | GRM5 | |
| SCHEMBL990042 | 0.88 | GRM5 (0.52) | GRM5 | |
| SCHEMBL990047 | 0.87 | GRM5 (0.53) | GRM5POLB | |
| SCHEMBL990246 | 0.77 | GRM5 (0.58) | GRM5 | |
| SCHEMBL3627130 | 0.77 | GRM5 (0.58) | GRM5 | |
| SCHEMBL990811 | 0.76 | GRM5 (0.52) | GRM5 | |
| SCHEMBL4880266 | 0.75 | GRM5 (0.53) | GRM5GAA | |
| SCHEMBL990750 | 0.75 | GRM5 (0.56) | GRM5 | |
| SCHEMBL3276845 | 0.74 | GRM5 (0.51) | GRM5L3MBTL1 | |
| SCHEMBL4656464 | 0.74 | GRM5 (0.51) | GRM5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130331568-A1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2013-12-12 | — | — | US | disclosed |
| US-8536229-B2 | Acetylene derivatives having MGluR 5 antagonistic activity | NOVARTIS AG (CH) | 2013-09-17 | — | — | US | disclosed |
| US-20120010263-A1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2012-01-12 | — | — | US | disclosed |
| US-20080146647-A1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2008-06-19 | — | — | US | disclosed |
| US-7348353-B2 | Acetylene derivatives having mGluR 5 antagonistic activity | NOVARTIS AG (CH) | 2008-03-25 | — | — | US | disclosed |
| EP-1453512-B8 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2006-07-19 | — | — | EP | disclosed |
| EP-1453512-B1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2006-05-31 | — | — | EP | disclosed |
| US-20050065191-A1 | Acetylene derivatives having mglur 5 antagonistic activity | NOVARTIS AG (CH) | 2005-03-24 | — | — | US | disclosed |
| EP-1453512-A1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | Novartis AG (CH) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003047581-A1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130331568-A1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | GRM5, GRM1, GRIK5 | GRM5 1/4885ALDH1A1 1423/4885L3MBTL1 3558/4885 |
| US-20080146647-A1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | GRM5, GRIK5, GRM1 | GRM5 1/4885ALDH1A1 1400/4885L3MBTL1 4416/4885 |
| US-20050065191-A1 | Acetylene derivatives having mglur 5 antagonistic activity | GRM5, GRM1, GRM2 | GRM5 1/4885ALDH1A1 1205/4885L3MBTL1 2889/4885 |
| US-20120010263-A1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | GRM5, GRIK5, GRM1 | GRM5 1/4885ALDH1A1 1400/4885L3MBTL1 4416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.