Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842885 | 0.91 | CDC7 (0.42) | CDC7CCNE1CDK2DBF4ROCK1 | |
| SCHEMBL16938035 | 0.85 | CDC7 (0.42) | CDC7CCNE1CDK2DBF4ROCK1 | |
| SCHEMBL16938037 | 0.82 | CDC7 (0.41) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL16938045 | 0.78 | ROCK1 (0.44) | CDC7CCNE1CDK2DBF4ROCK1 | |
| SCHEMBL6842852 | 0.76 | CDC7 (0.43) | CDC7CCNE1CDK2DBF4ROCK1 | |
| SCHEMBL6842851 | 0.75 | CDC7 (0.40) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL16938044 | 0.74 | CDC7 (0.38) | CDC7CCNE1CDK2DBF4ROCK1 | |
| SCHEMBL17089258 | 0.72 | CDC7 (0.33) | CDC7CCNE1CDK2DBF4NISCH | |
| SCHEMBL16938046 | 0.72 | CDC7 (0.36) | CDC7CCNE1CDK2DBF4PIK3CD | |
| SCHEMBL17089259 | 0.71 | JAK2 (0.36) | ROCK1CSNK1A1CDK9NISCHJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090601-B2 | Thiazole derivatives | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-07-28 | — | — | US | disclosed |