Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.47 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171583 | 0.94 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL13490563 | 0.90 | TRPC3 (0.58) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL13490560 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL171621 | 0.89 | GRIN2B (0.53) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL171472 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL171605 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL169370 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL13490558 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL13490730 | 0.80 | JAK2 (0.50) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 | |
| SCHEMBL171260 | 0.80 | FNTA (0.55) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426120-A1 | Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them | Fujifilm Finechemicals Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |