Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.57 |
| ▸ | JAK3 | P52333 | 11/20 | 0.57 |
| ▸ | JAK1 | P23458 | 10/20 | 0.57 |
| ▸ | EIF2AK4 | Q9P2K8 | 8/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1693880 | 1.00 | JAK2 (0.57) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL1693853 | 0.73 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL1693851 | 0.73 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL12067750 | 0.69 | JAK2 (0.52) | JAK2JAK3JAK1 | |
| SCHEMBL1996420 | 0.67 | JAK2 (0.47) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL1694180 | 0.66 | JAK2 (0.50) | JAK2JAK3JAK1 | |
| SCHEMBL1694185 | 0.66 | JAK2 (0.50) | JAK2JAK3JAK1 | |
| SCHEMBL2038337 | 0.66 | JAK2 (0.55) | JAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL2038340 | 0.66 | JAK2 (0.55) | JAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL1994455 | 0.65 | JAK2 (0.46) | JAK2JAK3JAK1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582703-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2013-04-24 | — | — | EP | claimed |
| WO-2011157397-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-12-22 | — | — | WO | claimed |