Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.83 |
| ▸ | BRAF | P15056 | 4/20 | 0.76 |
| ▸ | PLK4 | O00444 | 4/20 | 0.73 |
| ▸ | AURKA | O14965 | 4/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.73 |
| ▸ | ABL1 | P00519 | 4/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.73 |
| ▸ | LCK | P06239 | 4/20 | 0.73 |
| ▸ | CSF1R | P07333 | 4/20 | 0.73 |
| ▸ | LYN | P07948 | 4/20 | 0.73 |
| ▸ | KIT | P10721 | 4/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.73 |
| ▸ | FLT1 | P17948 | 4/20 | 0.73 |
| ▸ | FLT3 | P36888 | 4/20 | 0.73 |
| ▸ | BLK | P51451 | 4/20 | 0.73 |
| ▸ | NEK2 | P51955 | 4/20 | 0.73 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.73 |
| ▸ | STK3 | Q13188 | 4/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233442 | 0.98 | KDR (1.00) | KDRCYP3A4AURKBBRAFPLK4 | |
| SCHEMBL231766 | 0.96 | KDR (1.00) | KDRCYP3A4AURKBPLK4AURKA | |
| SCHEMBL3530163 | 0.91 | KDR (1.00) | KDRCYP3A4AURKBPLK4AURKA | |
| SCHEMBL3529454 | 0.91 | KDR (1.00) | KDRCYP3A4AURKBBRAFPLK4 | |
| SCHEMBL3530382 | 0.91 | KDR (0.93) | KDRCYP3A4AURKBPLK4AURKA | |
| SCHEMBL3530051 | 0.90 | KDR (0.91) | KDRCYP3A4AURKBPLK4AURKA | |
| SCHEMBL3558774 | 0.89 | KDR (0.89) | KDRCYP3A4AURKBPLK4AURKA | |
| SCHEMBL3571962 | 0.89 | KDR (0.88) | KDRCYP3A4AURKBPLK4AURKA | |
| SCHEMBL1694778 | 0.88 | KDR (0.76) | KDRCYP3A4AURKBBRAFPLK4 | |
| SCHEMBL3531408 | 0.88 | KDR (1.00) | KDRCYP3A4AURKBPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588098-A1 | COMPOUNDS FOR THE TREATMENT OF POSTERIOR SEGMENT DISORDERS AND DISEASES | Alcon Research, Ltd. (US) | 2013-05-08 | — | — | EP | claimed |
| WO-2012003141-A1 | COMPOUNDS FOR THE TREATMENT OF POSTERIOR SEGMENT DISORDERS AND DISEASES | ALCON RESEARCH, LTD. (US) | 2012-01-05 | — | — | WO | claimed |