Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 17/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695063 | 0.86 | PIK3R2 (0.45) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695065 | 0.86 | PIK3R2 (0.45) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695133 | 0.86 | PIK3CD (0.54) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL10147628 | 0.86 | PIK3CD (0.54) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL10146932 | 0.85 | PIK3CD (0.50) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695308 | 0.85 | PIK3CD (0.50) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL10147661 | 0.84 | PIK3CD (0.52) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695240 | 0.84 | PIK3CD (0.52) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL10147622 | 0.84 | PIK3R2 (0.52) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695339 | 0.84 | PIK3R2 (0.52) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |