Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694895 | 0.86 | PIK3CD (0.39) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1694893 | 0.83 | PIK3CD (0.35) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 | |
| SCHEMBL10146902 | 0.78 | PIK3CD (0.38) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1694712 | 0.71 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1694796 | 0.70 | TLR8 (0.36) | — | |
| SCHEMBL2716919 | 0.69 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 | |
| SCHEMBL2719469 | 0.68 | PIK3CD (0.42) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 | |
| SCHEMBL14815292 | 0.68 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 | |
| SCHEMBL1695303 | 0.68 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 | |
| SCHEMBL2717679 | 0.67 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CBPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |