Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695369 | 0.92 | PIK3CD (0.45) | MAPK8MAPK9MAPK10PIK3CDPIK3CG | |
| SCHEMBL1694804 | 0.87 | MAPK1 (0.43) | MAPK1ROCK2CSF1RMAPK8MAPK9 | |
| SCHEMBL1695028 | 0.86 | PIK3CD (0.46) | PDPK1PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL1694926 | 0.86 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1694983 | 0.85 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1694825 | 0.83 | PIK3CD (0.44) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1695192 | 0.83 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL10146881 | 0.83 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1695189 | 0.82 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1695193 | 0.82 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |