Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694861 | 0.89 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1694926 | 0.89 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1694983 | 0.87 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1694825 | 0.86 | PIK3CD (0.44) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1695471 | 0.86 | PIK3CD (0.38) | PIK3CDPIK3CGPIK3CBPIK3CARPS6KB1 | |
| SCHEMBL1695369 | 0.85 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1695193 | 0.85 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1694851 | 0.85 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1695189 | 0.85 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL1695297 | 0.85 | ADORA2A (0.39) | PIK3CDPIK3CGPIK3CBPIK3CAMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |