Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 12/20 | 0.40 |
| ▸ | GSK3B | P49841 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695471 | 0.95 | PIK3CD (0.38) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695147 | 0.86 | PDE4B (0.40) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695305 | 0.86 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695234 | 0.85 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695256 | 0.84 | PIK3CD (0.40) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695223 | 0.84 | MAPK8 (0.43) | MAPK1PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL1695017 | 0.84 | PIK3CD (0.45) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL10146960 | 0.83 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695329 | 0.83 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL1695297 | 0.83 | ADORA2A (0.39) | PIK3CDPIK3CBPIK3CGPIK3CACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |