Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695798 | 1.00 | GPBAR1 (0.55) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL1695753 | 0.93 | PDE10A (0.50) | GPBAR1CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL1695755 | 0.93 | PDE10A (0.50) | GPBAR1CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL1695914 | 0.92 | GPBAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL1695787 | 0.92 | GPBAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL1695449 | 0.92 | GPBAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL1695786 | 0.92 | GPBAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL1695917 | 0.92 | GPBAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7702354 | 0.92 | GPBAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL1695447 | 0.92 | GPBAR1 (0.48) | GPBAR1CYSLTR1CYSLTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138657-A1 | ARYL SUBSTITUTED OLEFINIC COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-11-10 | — | — | WO | claimed |
| WO-2011138657-A1 | ARYL SUBSTITUTED OLEFINIC COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-11-10 | — | — | WO | disclosed |