Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 20/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16964781 | 0.81 | MAPK1 (0.62) | MAPK1 | |
| SCHEMBL16964779 | 0.81 | MAPK1 (0.62) | MAPK1 | |
| SCHEMBL16965588 | 0.76 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL16965587 | 0.76 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL16830056 | 0.75 | MAPK1 (0.58) | MAPK1 | |
| SCHEMBL16830054 | 0.75 | MAPK1 (0.58) | MAPK1 | |
| SCHEMBL16965014 | 0.75 | MAPK1 (0.56) | MAPK1 | |
| SCHEMBL16965016 | 0.75 | MAPK1 (0.56) | MAPK1 | |
| SCHEMBL16965013 | 0.75 | MAPK1 (0.56) | MAPK1 | |
| SCHEMBL16965443 | 0.73 | MAPK1 (0.61) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900223-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-08-05 | — | — | EP | disclosed |