Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 20/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 17/20 | 0.60 |
| ▸ | AURKA | O14965 | 11/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318898 | 0.86 | PDPK1 (0.79) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL16966463 | 0.85 | PDPK1 (0.69) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1318139 | 0.85 | PDPK1 (0.69) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1320034 | 0.81 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1316676 | 0.80 | PDPK1 (0.63) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1316678 | 0.80 | PDPK1 (0.63) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1319884 | 0.78 | PDPK1 (0.80) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL16966478 | 0.77 | PDPK1 (0.84) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL16966479 | 0.77 | PDPK1 (0.84) | PDPK1AURKBAURKAROCK1PIK3CG | |
| SCHEMBL1318590 | 0.77 | PDPK1 (0.84) | PDPK1AURKBAURKAROCK1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | claimed |