Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 11/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.67 |
| ▸ | AURKA | O14965 | 6/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 2/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1316962 | 1.00 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1LRRK2 | |
| SCHEMBL1319014 | 0.90 | PDPK1 (0.70) | PDPK1AURKBAURKAROCK1LRRK2 | |
| SCHEMBL1317185 | 0.88 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1LRRK2 | |
| SCHEMBL1317000 | 0.82 | PDPK1 (0.71) | PDPK1AURKBAURKAROCK1LRRK2 | |
| SCHEMBL1317458 | 0.80 | PDPK1 (1.00) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL1318542 | 0.80 | PDPK1 (0.68) | PDPK1AURKBAURKAROCK1LRRK2 | |
| SCHEMBL1317180 | 0.80 | PDPK1 (0.56) | PDPK1AURKBAURKAROCK1LRRK2 | |
| SCHEMBL1321902 | 0.79 | PDPK1 (0.73) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL1319765 | 0.79 | PDPK1 (0.71) | PDPK1AURKBAURKAROCK1LRRK2 | |
| SCHEMBL1318863 | 0.78 | PDPK1 (0.54) | PDPK1AURKBAURKAROCK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |