Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.60 |
| ▸ | JAK1 | P23458 | 18/20 | 0.60 |
| ▸ | JAK2 | O60674 | 17/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696826 | 0.86 | JAK1 (0.56) | JAK3JAK1JAK2 | |
| SCHEMBL1696811 | 0.85 | JAK1 (0.55) | JAK3JAK1JAK2 | |
| SCHEMBL12147455 | 0.82 | JAK1 (0.64) | JAK3JAK1JAK2 | |
| SCHEMBL1368628 | 0.82 | JAK3 (0.60) | JAK3JAK1JAK2 | |
| SCHEMBL1696822 | 0.81 | JAK1 (0.63) | JAK3JAK1JAK2 | |
| SCHEMBL1696845 | 0.81 | JAK3 (0.62) | JAK3JAK1JAK2 | |
| SCHEMBL1368793 | 0.80 | JAK3 (0.61) | JAK3JAK1JAK2 | |
| SCHEMBL1696824 | 0.79 | JAK3 (0.60) | JAK3JAK1JAK2 | |
| SCHEMBL17403256 | 0.79 | JAK1 (0.65) | JAK3JAK1JAK2 | |
| SCHEMBL1368577 | 0.79 | JAK1 (0.69) | JAK3JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011144585-A1 | PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |