Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.56 |
| ▸ | JAK2 | O60674 | 12/20 | 0.56 |
| ▸ | JAK1 | P23458 | 12/20 | 0.56 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1370810 | 0.87 | JAK3 (0.75) | JAK3JAK2JAK1PTGER4 | |
| SCHEMBL1369663 | 0.86 | JAK3 (0.62) | JAK3JAK2JAK1 | |
| SCHEMBL1370816 | 0.85 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL14655458 | 0.84 | JAK3 (0.74) | JAK3JAK2JAK1 | |
| SCHEMBL15755322 | 0.84 | JAK3 (0.59) | JAK3JAK2JAK1 | |
| SCHEMBL15755880 | 0.81 | JAK3 (0.77) | JAK3JAK2JAK1PTGER4 | |
| SCHEMBL12147966 | 0.80 | JAK3 (0.74) | JAK3JAK2JAK1 | |
| SCHEMBL14795094 | 0.78 | JAK3 (0.60) | JAK3JAK2JAK1DHODH | |
| Ethylamine SCHEMBL1372020 | 0.78 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL17413020 | 0.78 | JAK3 (0.52) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571880-A1 | PYRROLO [2, 3 - B]PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144585-A1 | PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |