Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | JAK1 | P23458 | 5/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368301 | 0.85 | JAK2 (0.63) | SYKKCNH2JAK2JAK1JAK3 | |
| SCHEMBL1369134 | 0.84 | JAK2 (0.64) | SYKKCNH2JAK2JAK1JAK3 | |
| SCHEMBL1370638 | 0.81 | JAK3 (0.66) | SYKJAK2JAK1JAK3MAPK1 | |
| SCHEMBL2484874 | 0.81 | MAPK1 (0.56) | SYKKCNH2JAK2JAK1JAK3 | |
| SCHEMBL1369186 | 0.78 | JAK3 (0.68) | SYKJAK2JAK1JAK3MAPK1 | |
| SCHEMBL12333270 | 0.78 | JAK2 (0.51) | SYKJAK2JAK1JAK3MAPK1 | |
| SCHEMBL12299590 | 0.78 | JAK2 (0.51) | SYKJAK2JAK1JAK3MAPK1 | |
| SCHEMBL12333704 | 0.76 | JAK3 (0.46) | SYKKCNH2JAK2JAK1JAK3 | |
| SCHEMBL2378812 | 0.75 | JAK2 (0.72) | JAK2JAK1JAK3 | |
| SCHEMBL12333691 | 0.75 | JAK3 (0.48) | SYKKCNH2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571880-A1 | PYRROLO [2, 3 - B]PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144585-A1 | PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |