Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 1.00 |
| ▸ | TAF1 | P21675 | 6/20 | 1.00 |
| ▸ | PLK1 | P53350 | 11/20 | 0.77 |
| ▸ | PLK3 | Q9H4B4 | 7/20 | 0.77 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.77 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.77 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.77 |
| ▸ | CLK2 | P49760 | 3/20 | 0.77 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.77 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.77 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.77 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.77 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.77 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.77 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.77 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.77 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.77 |
| ▸ | EGFR | P00533 | 2/20 | 0.77 |
| ▸ | FES | P07332 | 2/20 | 0.77 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16971929 | 1.00 | BRD4 (1.00) | BRD4TAF1PLK1PLK3ALK | |
| SCHEMBL25787073 | 0.94 | BRD4 (0.89) | BRD4TAF1PLK1PLK3ALK | |
| SCHEMBL12838245 | 0.89 | PLK1 (0.91) | BRD4TAF1PLK1PLK3ALK | |
| SCHEMBL17507123 | 0.88 | BRD4 (0.79) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL17507124 | 0.88 | BRD4 (0.79) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL4515808 | 0.88 | BRD4 (0.82) | BRD4TAF1PLK1PLK3ALK | |
| Bromide SCHEMBL30394276 | 0.88 | PLK1 (0.90) | BRD4TAF1PLK1PLK3ALK | |
| SCHEMBL12766938 | 0.87 | BRD4 (0.83) | BRD4TAF1PLK1PLK3ALK | |
| Bi-2536 SCHEMBL29395966 | 0.87 | BRD4 (1.00) | BRD4TAF1PLK1PLK3ALK | |
| Bi-2536 SCHEMBL372489 | 0.87 | BRD4 (1.00) | BRD4TAF1PLK1PLK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099171-A1 | DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2016-12-07 | — | — | EP | disclosed |
| US-20160347750-A1 | DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-01 | — | — | US | disclosed |
| WO-2015117055-A1 | DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347750-A1 | DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF | BRDT, BRD4, BRD3 | BRD4 2/4885TAF1 2161/4885PLK1 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.