Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.61 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1697251 | 1.00 | SCN9A (0.61) | SCN9ASCN3ABCHEMAOBPARP15 | |
| SCHEMBL1697243 | 1.00 | SCN9A (0.61) | SCN9ASCN3ABCHEMAOBPARP15 | |
| SCHEMBL8638250 | 0.91 | SCN9A (0.50) | SCN9ASCN3ABCHENPC1RAB9A | |
| SCHEMBL2939300 | 0.83 | MCL1 (0.44) | SCN9ARAB9ALMNAKMT2AKDM4E | |
| SCHEMBL2934213 | 0.83 | MCL1 (0.44) | SCN9ARAB9ALMNAKMT2AKDM4E | |
| SCHEMBL2933337 | 0.83 | MCL1 (0.44) | SCN9ARAB9ALMNAKMT2AKDM4E | |
| SCHEMBL1672184 | 0.81 | MAOB (0.62) | SCN9ABCHEMAOBMAOA | |
| SCHEMBL1665718 | 0.81 | MAOB (0.62) | SCN9ABCHEMAOBMAOA | |
| SCHEMBL2940856 | 0.81 | MAOB (0.62) | SCN9ABCHEMAOBMAOA | |
| Water SCHEMBL1672445 | 0.81 | MAOB (0.61) | SCN9ABCHEMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40259-E1 | side effects reduction; compounds active on the central nervous system; chronic and neuropathic pain, anti-epileptic, anti-Parkinson, neuroprotective, antidepressant, antispastic and hypnotic agents; 2-[4-(3-fluorobenzyloxy)benzylamino]-2-methylpropanamide | NEWRON PHARMACEUTICALS, S.P.A. (IT) | 2008-04-22 | — | — | US | claimed |
| EP-2563355-A1 | PROCESS FOR THE PRODUCTION OF RALFINAMIDE METHANESULFONATE SALTS OR THEIR R-ENANTIOMERS | Newron Pharmaceuticals S.p.A. (IT) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134763-A1 | PROCESS FOR THE PRODUCTION OF RALFINAMIDE METHANESULFONATE SALTS OR THEIR R-ENANTIOMERS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2011-11-03 | — | — | WO | disclosed |